BERKELEY -- UC Berkeley will eliminate more than 200 full-time jobs this week and there will be some actual layoffs, the first related to a state budget cut since the early 1990s.

Layoffs are a last resort, but the campus faces an estimated $25.5 million state funding cut, University of California, Berkeley Provost Paul Gray said in a statement Wednesday. The number of layoffs is not fully known, Gray said, estimating the campus must eliminate the equivalent of more than 200 full-time positions.

"Many of these have been left open in anticipation of state funding cuts," he said. "These layoffs should not affect classroom instruction."

The announcement makes Berkeley the first public university in the Bay Area to announce major layoffs, although other UC and California State University campuses have also said layoffs may be inevitable. UC San Francisco has placed 14 clerks on layoff status, but the university hopes to find places for them, a union official said.

"For the past two years, we've been able to limit layoffs to select areas, but the cuts the state made to UC's funding ... are so deep that it's almost a certainty that all UC locations will suffer job impacts of one kind or another," UC spokesman Paul Schwartz said in a statement.

CSU spokeswoman Clara Potes-Fellow said 60 layoff notices have been distributed at five locations statewide -- Cal State Hayward, the system Chancellor's Office and campuses in Fresno, Humboldt and Los Angeles. But she said only four employees have lost their jobs, and another 23 have been given new jobs at the same campus. Layoffs are pending for the remaining 33 employees.

CSU has frozen or eliminated 2,300 faculty and staff positions throughout the state as it copes with a $345 million cut from the state. The 10-campus UC system faces $410 million in state funding cuts for the fiscal year that began July 1. Both UC and CSU have raised tuition 30 percent for the fall term.

This is the first time since the early 1990s there have been campus-wide layoffs caused by state budget cuts, UC Berkeley spokeswoman Marie Felde said.

UC Berkeley employees and union officials contacted Wednesday said many departments have been preparing for cuts as the debate unraveled in the Legislature. A campus-wide program dubbed "START" allows workers to take voluntary pay cuts and reduce the hours they work an equivalent amount.

Campus library employee Norah Foster said she accepted a 10 percent pay cut and now takes Friday afternoons off. "I thought it would be a nice thing to have a long weekend," Foster said. "But I just got my first paycheck ... and it hurts."

Margy Wilkinson, chief steward for the Coalition of University Employees, which represents 18,000 UC clerical workers, said the union hasn't been formally notified about cuts. "But we know from past experience when faced with budgetary problems, they always start layoffs at the bottom."

Union members wonder how UC can lay off clerical workers when it gave UC Senior Vice President for Business and Finance Joseph Mullinix a $58,100 pay raise and a $20,000 bonus on May 1, she said.

UC regents raised Mullinix's salary to $350,000 -- a 19.9 percent raise -- because he had received an offer from a competing university, according to information from the UC President's Office.

The $20,000 is incentive pay to be awarded annually by the UC president, depending on performance. Mullinix oversees the university's multi-billion dollar investments and budget.