Campus: Cal Poly, Pomona -- February 29, 2000

Pomona Team picCal Poly Pomona Team Discovers New Way To Protect Meat From Harmful Bacteria

A new way to protect consumers from harmful bacteria that may be found in meat has been discovered by scientists from California State Polytechnic University, Pomona. The results of their research were presented at a USDA-sponsored conference on foodborne bacteria held here today.

The breakthrough involves applying a small amount of lactoferrin from cow's milk to the surface of meat during processing. Lactoferrin is a naturally occurring protein in mammalian milk that is credited with protecting infants from harmful bacteria while their immune systems are developing. By discovering how to activate the lactoferrin molecule, scientists were able to mimic its function on meat.

Laboratory tests showed the activated form of lactoferrin to be effective against more than 30 different kinds of harmful bacteria, including E. coli O157:H7, Salmonella and Campylobacter. Lactoferrin does not change the taste, flavor, color, or appearance of meat.

"We borrowed a page from Mother Nature," said A.S. "Narain" Naidu, Ph.D., a medical microbiologist who heads the Center for Antimicrobial Research at Cal Poly Pomona. "We have taken a natural compound with antimicrobial properties and discovered a way to make it work on meat surfaces to provide a protective barrier against harmful bacteria."

The university's research involved applying an activated form of lactoferrin to meat tissue surfaces that had been purposefully contaminated with extremely high concentrations of bacteria. The lactoferrin formulation proved effective in removing E. coli O157:H7, which has been linked to recent meat-related illnesses.

"The research objective was to use lactoferrin to prevent bacteria from attaching and multiplying on meat surfaces using the same natural compound that has functioned this way in mammals for thousands of years," said Naidu, who has studied lactoferrin and other natural antimicrobial agents for nearly 20 years.

According to Naidu, the amount of activated lactoferrin required to protect a serving of meat is thousands of times less than the amount of lactoferrin found in a single glass of milk. Lactoferrin currently is produced from whey, a by-product in the manufacture of cheese from cow's milk.

Naidu said activated lactoferrin can be applied easily to meat products at the processing plant as an added step to the meat industry's existing multiple-hurdle bacterial control process. Because lactoferrin remains on the meat surface, he said the compound may provide lasting protection from bacterial exposure.

Naidu has studied the lactoferrin molecule as part of a distinguished career investigating human illness caused by bacteria present in the human digestive tract. He has already published more than 50 peer-reviewed papers surrounding natural antimicrobial agents and intends to publish a series of scientific papers on the subject later this year. Earlier in his career, Naidu led a medical microbiology team in India/Europe that helped bring a solution to toxic shock syndrome by understanding how to prevent bacteria from colonizing on tissue surfaces.

He recently was awarded a four-year grant from the National Institutes of Health to study lactoferrin in biomedical applications.

Research funding and support were provided to Cal Poly Pomona by Farmland National Beef, the only farmer-rancher owned beef processor in the country and the fourth-largest beef processor overall. Based in Kansas City, Mo., Farmland National Beef Company is jointly owned by Farmland Industries, Inc., and U.S. Premium Beef.

Located on the eastern edge of Southern California's San Gabriel Valley, Cal Poly Pomona is part of the 23-campus California State University system. Its 2,200 faculty and staff serve more than 18,000 students from 33 states and 116 countries worldwide. Offering degrees in bachelor's, master's and certificate programs, its mission is to advance learning and knowledge by linking theory and practice while preparing students for lifelong learning, leadership and careers.

The Center for Antimicrobial Research was established in 1998 to perform basic and applied research on novel antimicrobial agents and their potential application in food safety, oral health, animal sciences, water quality and public health.

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